For Healthcare Professionals

Study to Evaluate the Efficacy, Safety, and Tolerability of Valbenazine as an Adjunctive Treatment for Schizophrenia

clipboard-pencil

About the study

This primary objective for this study is to evaluate the effect of adjunctive valbenazine versus placebo on symptoms of schizophrenia in participants who have inadequate response to antipsychotic treatment.
user-3

Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Key Inclusion Criteria:

  1. Medically confirmed diagnosis of schizophrenia
  2. Participant is receiving a stable regimen of background antipsychotic medication
  3. Plasma levels for at least 1 of the participant's antipsychotic medications must be detectable by an available assay
  4. Participant is an outpatient with stable symptomatology
  5. Participant must have an adult informant (for example, a family member, relative, partner, social worker, caseworker, residential facility staff, or nurse)

EXCLUSION CRITERIA

Key Exclusion Criteria:

  1. Has a history of treatment resistant schizophrenia
  2. Have a clinically significant unstable medical condition in the judgement of the investigator or any laboratory value outside the normal range that is considered by the investigator to be clinically significant at the screening visit
  3. Prior (within 6 months of Screening) or concomitant use of any vesicular monoamine transporter 2 (VMAT2) inhibitor (that is, valbenazine, reserpine, tetrabenazine, deutetrabenazine); or a history of intolerance to VMAT2 inhibitors
pin location

Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.

Study’s details


Contition

Schizophrenia

Age (in years)

13+

Phase

Phase 3

Participants needed

400

Est. Completion Date

Sep 30, 2025

Treatment type

Interventional


Sponsor

Neurocrine Biosciences

ClinicalTrials.gov identifier

NCT05654870

Study number

NBI-98854-ATS3020

Understanding Clinical Trials


Get answers to your questions about clinical trials.What is a clinical research?What does taking part in clinical trials involve?What should I ask the trial doctor?
Vector

Interested?

Sign up to save your favorites, 
receive newsletters, resources, and alerts 
about clinical trials related to your conditions of interest.