Study of SGR-1505 in Mature B-Cell Neoplasms

Inclusion Criteria:

1. Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy.
2. Subject must have measurable or detectable disease according to the applicable disease-specific classification system.
3. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
4. Life expectancy ≥ 12 weeks.

Exclusion Criteria:

1. For a subject with indolent NHL and CLL/SLL, the subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit) and has an indication for treatment.
2. Subject has previous invasive malignancy in the last 2 years.
3. Subject has a known allergy to SGR-1505 or excipients of SGR-1505.
4. Subject has symptomatic or active CNS involvement of disease.
5. Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that would place the participant at increased risk to the use of an investigational drug.