For Healthcare Professionals

Safety, Pharmacokinetics, and Antitumor Activity of BGB-B167 Alone and in Combination With Tislelizumab (BGB-A317) in Participants With Advanced Solid Tumors


About the study

This study will evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of BGB-B167 monotherapy and in combination with tislelizumab (BGB-A317) in participants with select advanced solid tumors.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Age 18 or older
  2. Participants with histologically or cytologically confirmed unresectable locally advanced or metastatic solid tumors previously treated with standard systemic therapy or for whom treatment is not available, not tolerated, or refused, or not expected to provide significant clinical benefit or be tolerated in the medical judgement of the investigator
  3. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 1
  4. Adequate organ function as indicated by laboratory values during screening or ≤ 7 days before the first dose of study drug(s)


Exclusion Criteria:

  1. Active leptomeningeal disease or uncontrolled, untreated brain metastasis
  2. Active autoimmune diseases or history of autoimmune diseases that may relapse
  3. Any malignancy ≤ 3 years before the first dose of study drug(s) except for the specific cancer under investigation in this study and any locally recurring cancer that has been treated with curative intent
  4. History of severe hypersensitivity reactions to other monoclonal antibody products or their excipients
  5. Women who are pregnant or are breastfeeding

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

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Study Locations

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How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Solid Tumor

Age (in years)



Phase 1

Participants needed


Est. Completion Date

Aug 5, 2025

Treatment type



BeiGene identifier


Study number


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