Study of ARO-APOC3 in Adults With Dyslipidemia
About the study
This is an open-label extension of the parent studies AROAPOC3-2001 and AROAPOC3-2002. Adult participants with dyslipidemia who completed the blinded 12-month period from either parent study and continue to meet eligibility criteria have the option to be enrolled into this study. Eligible enrolled participants will initially receive open-label ARO-APOC3 at the assigned dose level until a final dose is selected, at which point all participants will be transitioned to the selected dosing regimen.
Who can take part
You may be eligible to participate in the study if you meet the following criteria:
INCLUSION CRITERIA
Inclusion Criteria:
- Adults who are nonpregnant, nonlactating and do not plan to become pregnant during the study
- Able and willing to provide written informed consent
- Completed the 48-week study treatment period in the parent study
EXCLUSION CRITERIA
Exclusion Criteria:
- Subject was permanently discontinued from ARO-APOC3 in the parent study due to elevated glycated hemoglobin (HbA1c), aspartate aminotransferase (AST) or alanine aminotransferase (ALT)
- Any new condition or worsening of existing condition or any other situation that would make the subject unsuitable for enrollment, could interfere with the subject participating in or completing the study, would make it difficult to comply with protocol requirements or put the subject at additional safety risk
- Unwilling to limit alcohol consumption to within moderate limits for the duration of the study
Study Locations
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How to Apply
Contact the study center to learn if this study is a good match for you.
Study’s details
Contition
Dyslipidemias
Age (in years)
18+
Phase
Phase 2
Participants needed
418
Est. Completion Date
Oct 31, 2025
Treatment type
Interventional
Sponsor
Arrowhead Pharmaceuticals
ClinicalTrials.gov identifier
NCT05413135
Study number
AROAPOC3-2003
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