For Healthcare Professionals

Study of Novel Regimens in Relapsed or Refractory Multiple Myeloma


About the study

This is a multicenter, open-label, phase I/II clinical study, to assess the safety, tolerability, antitumor activity, pharmacokinetics and pharmacodynamics of EOS884448 (also known as EOS-448 or GSK4428859A), alone or in combination with iberdomide with and without dexamethasone in participants with relapsed/refractory multiple myeloma (RRMM).

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. All participants must have a documented diagnosis of relapse/refractory Multiple Myeloma and have measurable disease as defined per IMWG criteria.
  2. All participants must have received at least 3 prior lines of MM therapy with IMiD, PI and Anti-CD-38, and progressed on their last therapy (prior BCMA targeted therapy allowed).
  3. All participants must have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0,1or 2.
  4. All participants must have adequate organ function.
  5. Females of childbearing potential (FCBP) or male participant must agree to follow contraception requirements.


Exclusion Criteria:

  1. All participants with non-secretory MM
  2. All participants with known auto-immune disease
  3. All participants with history of life-threatening toxicity related to prior immune therapy.
  4. All participants with active graft versus host disease after allogeneic stem cell transplantation.
  5. All participants with active, unstable cardiovascular function.
  6. All participants with active infection requiring systemic therapy.
  7. All participants with hypersensitivity to any of the treatments.
  8. All participants with any active gastrointestinal dysfunction that prevents the patient from swallowing tablets or interferes with absorption of study treatment.
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Multiple Myeloma

Age (in years)



Phase 1/Phase 2

Participants needed


Est. Completion Date

Dec 31, 2025

Treatment type



iTeos Therapeutics identifier


Study number


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