For Healthcare Professionals

A Trial to Assess the Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With PLD


About the study

The purpose of the trial is to compare the effectiveness and safety of 2 treatment regimens of CAM2029 (given weekly or every 2 weeks) to placebo in participants with symptomatic PLD, either isolated as in autosomal dominant PLD (ADPLD) or associated with autosomal dominant polycystic kidney disease (ADPKD). In the Treatment Period of the trial, participants will be allocated at random to 1 of the 3 treatment arms in a 1:1:1 ratio. After completing the Treatment Period (53 weeks) participants may proceed to a 24-week open-label extension part of the trial and then only receive the same CAM2029 treatment. The active ingredient in CAM2029, octreotide, is administered as a subcutaneous depot using Camurus' FluidCrystal® technology.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Male or female patient, ≥18 years at screening
  2. Diagnosis of PLD (associated with ADPKD or isolated as in ADPLD) as defined by htTLV ≥1800 mL/m at screening
  3. Presence of at least 1 of the following PLD-related symptoms within 2 weeks before screening: bloating, fullness in abdomen, lack of appetite, feeling full quickly after beginning to eat, acid reflux, nausea, rib cage pain or pressure, pain in side, abdominal pain, back pain, shortness of breath after physical exertion, limited in mobility, concern about abdomen getting larger, dissatisfied by the size of abdomen
  4. Not a candidate for, or not willing to undergo, surgical intervention for hepatic cysts during the trial


Exclusion Criteria:

  1. Surgical intervention for PLD within 3 months before screening
  2. Treatment with a somatostatin analogue (SSA) within 3 months before screening
  3. Non-responsive to previous treatment of PLD with an SSA as per the Investigator's assessment
  4. Systematic cholelithiasis within 3 months before screening or previous medical history of cholelithiasis induced by SSAs unless treated with cholecystectomy
  5. Presence of extrahepatic cysts that, in the Investigator's opinion, may prevent the patient from safely participating in the trial
  6. Severe kidney disease, as defined by eGFR <30 mL/min/1.73^m2
  7. Severe liver disease defined as liver cirrhosis of Child-Pugh class C
  8. Any other current or prior medical condition that may interfere with the conduct of the trial or the evaluation of its results in the opinion of the Investigator
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Polycystic Liver Disease

Age (in years)



Phase 2/Phase 3

Participants needed


Est. Completion Date

Jun 30, 2025

Treatment type



Camurus AB identifier


Study number


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