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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)


About the study

To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Key Inclusion Criteria:

  1. Between 18-80 years of age
  2. Individuals who know they have an Alzheimer's disease-causing mutation.
  3. Are within -10 to + 10 years of the predicted or actual age of cognitive symptom onset.
  4. Cognitively normal or with mild cognitive impairment or mild dementia, Clinical Dementia Rating (CDR) of 0-1 (inclusive)
  5. Fluency in DIAN-TU trial approved language and evidence of adequate premorbid intellectual functioning
  6. Able to undergo Magnetic Resonance Imaging (MRI), Lumbar Puncture (LP), Positron Emission Tomography (PET), and complete all study related testing and evaluations.
  7. For women of childbearing potential, if partner is not sterilized, participant must agree to use effective contraceptive measures (hormonal contraception, intra-uterine device, sexual abstinence, barrier method with spermicide).
  8. Adequate visual and auditory abilities to perform all aspects of the cognitive and functional assessments.
  9. Has a Study Partner who in the investigator's judgment is able to provide accurate information as to the subject's cognitive and functional abilities, who agrees to provide information at the study visits which require informant input for scale completion.


Key Exclusion Criteria:

  1. Significant neurologic disease (other than AD) or psychiatric disease that may currently or during the course of the study affect cognition or participant's ability to complete the study.
  2. At high risk for suicide, e.g., significant suicidal ideation or attempt within last 12 months. Current stable mild depression or current use of antidepressant medications is not exclusionary.
  3. History or presence of brain MRI scans indicative of any other significant abnormality
  4. Substance or alcohol use disorder currently or within the past 1 year
  5. Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, or foreign metal objects in the eyes, skin or body which would preclude MRI scan.
  6. History or presence of clinically significant cardiovascular disease, hepatic/renal disorders, infectious disease or immune disorder, or metabolic/endocrine disorders
  7. Anticoagulants except low dose (≤ 325 mg) aspirin.
  8. Have been exposed to a monoclonal antibody targeting beta amyloid peptide within the past six months.
  9. History of cancer within the last 5 years, except basal cell carcinoma, non-squamous skin carcinoma, prostate cancer or carcinoma in situ with no significant progression over the past 2 years.
  10. Positive urine or serum pregnancy test or plans or desires to become pregnant during the course of the trial.
  11. Subjects unable to complete all study related testing, including implanted metal that cannot be removed for MRI scanning, required anticoagulation and pregnancy.
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Study Locations

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How to Apply

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Study’s details


Alzheimers Disease,Dementia,Alzheimers Disease, Familial

Age (in years)

18 - 80


Phase 2/Phase 3

Participants needed


Est. Completion Date

Oct 31, 2027

Treatment type



Washington University School of Medicine identifier


Study number

DIAN-TU-001 E2814

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