DETERMINE: Detemir vs NPH

About the study

The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:

Inclusion criteria will include pregnant women with pre-existing T2DM and GDM who requiring insulin to manage their blood sugars in pregnancy.

EXCLUSION CRITERIA

Exclusion Criteria:

Multiple Gestation
Type 1 Diabetes mellatus
Age < 18
Known or suspected hypersensitivity to NPH or insulin detemir
Known fetal major malformations
Chronic renal or hepatic insufficiency
Known to be HIV, Hepatitis B, or Hepatitis C positive
Indication for planned premature delivery (placenta accrete, or prior classical cesarean delivery)
Insulin dependent before conception

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Contition

Gestational Diabetes,Diabetes Mellitus, Type 2

Age (in years)

18+

Phase

Phase 2

Participants needed

336

Est. Completion Date

Jun 30, 2025

Treatment type

Interventional

Sponsor

University of California, Los Angeles

ClinicalTrials.gov identifier

NCT05124457

Study number

DETERMINE