For Healthcare Professionals

An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive A Kidney Transplant


About the study

The primary objective of the study is to assess adverse events (AEs) and serious adverse events (SAEs) in kidney transplant recipients previously treated with REGN5459 or REGN5458 in the R5459-RT-1944 study. The secondary objectives of the study are to evaluate each of the following in kidney transplant recipients previously treated with REGN5459 or REGN5458: Rates and classification of antibody-mediated and T-cell-mediated kidney allograft rejection Graft survival Allograft function Delayed allograft function Anti-human leukocyte antigen (HLA) alloantibody levels and calculated panel-reactive antibody (cPRA) Emergence of de novo donor-specific antibodies Circulating immunoglobulin (Ig) classes (isotypes) Pharmacokinetics (PK) of REGN5459 or REGN5458

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Received at least 1 dose of treatment with REGN5459 or REGN5458 in study R5459-RT-1944
  2. Received, or scheduled to receive after acceptable crossmatching, a kidney transplant while enrolled in study R5459-RT-1944
  3. Willing and able to comply with clinic visits and study-related procedures
  4. Provide informed consent signed by study patient or legally acceptable representative


Exclusion Criteria:

There are no exclusion criteria for this study.

Note: Other protocol defined Inclusion/Exclusion criteria may apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Chronic Kidney Disease (CKD)

Age (in years)

18 - 70

Participants needed


Est. Completion Date

May 21, 2026

Treatment type



Regeneron Pharmaceuticals identifier


Study number


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