Acute Cognition and Exercise
About the study
The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims:
Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity.
Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity.
Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.
Who can take part
You may be eligible to participate in the study if you meet the following criteria:
INCLUSION CRITERIA
Inclusion Criteria:
- Between ages 18 and 35
- No prior diagnosis of neurological disorders (e.g., autism spectrum disorder)
- No prior diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
- No physical disability that would preclude the participant from completing a VO2max test
- Corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
- Not pregnant
- BMI between 18.5 and 25.0 kg/m2, or BMI greater than 30.0 kg/m2
- Readiness for exercise (determined through PAR-Q)
EXCLUSION CRITERIA
Exclusion Criteria:
- <18 years and >35 years
- Diagnosis of neurological disorders (e.g., autism spectrum disorder)
- Diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
- Physical disability that would preclude the participant from completing a VO2max test
- Lack of corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
- Pregnancy
- BMI less than 18.5 kg/m2 or BMI greater than 25.0 but less than 30.0 kg/m2
Study Locations
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How to Apply
Contact the study center to learn if this study is a good match for you.
Study’s details
Contition
Obesity
Age (in years)
18 - 35
Phase
Not Applicable
Participants needed
36
Est. Completion Date
Sep 2, 2022
Treatment type
Interventional
Sponsor
University of Illinois at Urbana-Champaign
ClinicalTrials.gov identifier
NCT05078203
Study number
ACE
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