Etrasimod Versus Placebo for the Treatment of Moderately Active Ulcerative Colitis

Inclusion Criteria:

1. Diagnosed with Ulcerative Colitis (UC) ≥ 3 months prior to screening
2. Active UC confirmed by endoscopy
3. Moderately active UC defined as a modified Mayo score of 4 to 6 and an endoscopic score ≥ 2 and rectal bleeding score ≥ 1
4. Received a surveillance colonoscopy within 12 months before baseline

Exclusion Criteria:

1. Severe extensive colitis
2. Diagnosis of Crohn's disease or indeterminate colitis or the presence or history of a fistula consistent with Crohn's disease
3. Diagnosis of microscopic colitis, ischemic colitis, or infectious colitis
4. Hospitalization for exacerbation of UC requiring intravenous steroids within 12 weeks prior to or after screening