For Healthcare Professionals

Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities

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About the study

The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants or other causalities.
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:

  1. For MYH7 and TTN cohorts, must have diagnosis of primary DCM (dilated cardiomyopathy), clinically stable and due to probably disease-causing variant of MYH7 or TTN
  2. Has adequate acoustic windows for echocardiography
  3. Maximum of 3 family members with same variant can be enrolled
  4. For the cohort of primary DCM due to causalities other than MYH7 and TTN, participant must have diagnosis of primary DCM with a cause not related to MYH7 or TTN variants

EXCLUSION CRITERIA

Exclusion Criteria:

  1. Significant structural cardiac abnormalities including valvar dysfunction on Screening transthoracic echo(s)
  2. Routinely scheduled outpatient intravenous (IV) infusions for heart failure (e.g., inotropes, afterload reduction, or diuretics)
  3. Presence of protocol specified laboratory abnormalities at Screening
  4. Recent acute coronary syndrome or angina pectoris (<90 days)
  5. Recent hospitalization for heart failure (<90 days)
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.

Study’s details


Contition

Primary Familial Dilated Cardiomyopathy

Age (in years)

18 - 80

Phase

Phase 2

Participants needed

40

Est. Completion Date

Jan 3, 2025

Treatment type

Interventional


Sponsor

Bristol-Myers Squibb

ClinicalTrials.gov identifier

NCT04572893

Study number

CV028-005

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