For Healthcare Professionals

Open-label Study to Determine the Maximum Tolerated Dose of DSG3-CAART in Mucosal-dominant PV Patients (mPV)


About the study

Mucosal-dominant pemphigus vulgaris (mPV) is a B-cell mediated autoimmune disorder in which painful blisters are formed on the mucosal membrane, including the mouth, nose, throat, eyelids, anus, and genitals. This phase 1 study is being conducted to find the maximum tolerated dose and optimal fractionated infusion schedule of an investigational cell therapy, DSG3-CAART, that can be given to patients with mPV who are inadequately managed by standard therapies. DSG3-CAART may potentially lead to complete and durable remission of disease.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Confirmed diagnosis of mPV by prior or screening biopsy and prior positive anti- DSG3 antibody ELISA
  2. mPV inadequately managed by at least one standard immunosuppressive therapies
  3. Active mPV at screening
  4. Anti-DSG3 antibody ELISA positive at screening


Exclusion Criteria:

  1. Active cutaneous lesions associated with PV that indicates mucocutaneous rather than mucosal-dominant disease
  2. Rituximab in last 12 months unless PV symptoms have recently worsened or anti-DSG3 antibody titers have recently increased
  3. Prednisone > 0.25mg/kg/day
  4. Other autoimmune disorder requiring immunosuppressive therapies
  5. Investigational treatment in last 6 months
  6. Absolute lymphocyte count < 1,000/µL at screening
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.
Phone iconCall +1 267 759 3100Email iconEmail Study Center

Study’s details


Mucosal -Dominant Pemphigus Vulgaris

Age (in years)



Phase 1

Participants needed


Est. Completion Date

Sep 30, 2026

Treatment type



Cabaletta Bio identifier


Study number


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