For Healthcare Professionals

Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)


About the study

This is a randomized, double-blind, placebo-controlled, parallel-group, international, multicenter, Phase 3 study to evaluate the efficacy and safety of repeat dosing of benralizumab 30 mg administered subcutaneously (SC) versus placebo in patients with severe nasal polyposis.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion criteria:

  1. Female or male patients aged 18 to 75 years inclusive
  2. Stable Intranasal corticosteroids (INCS) use for at least 4 weeks prior to enrolment and throughout screening
  3. History of treatment with systemic corticosteroids (SCS) or prior surgery for CRSwNP
  4. Bilateral sinonasal polyposis with a nasal polyp score (NPS) of 5 at enrolment and randomization (unilateral score of at least 2 for each nostril)
  5. Ongoing symptoms for at least 12 weeks prior to enrolment
  6. Patient-reported moderate to severe nasal blockage score (NBS) ≥2 at enrolment
  7. Bi-weekly mean NBS ≥ 1.5 at randomization
  8. SNOT-22 total score ≥ 20 at enrolment and randomization
  9. Documented physician-diagnosed asthma
  10. Blood eosinophil count of >2% or ≥150/μL at enrolment


Exclusion criteria:

Any nasal and/or sinus surgery within 3 months prior to enrolment

Patients with conditions that makes them non evaluable for the co-primary efficacy endpoint including but not limited to:

  1. Unilateral antrochoanal polyps
  2. Nasal septal deviation that occludes at least one nostril
  3. Current rhinitis medicamentosa
  4. Allergic fungal rhinosinusitis or allergic fungal sinusitis;
  5. Clinically important comorbidities that may put the patient at risk, or may confound interpretation of clinical efficacy and/or safety results
  6. Receipt of SCS for within 4 weeks prior to screening, or a scheduled SCS treatment during the study period.
  7. Receipt of any marketed or investigational biologic product within 6 months of enrolment
  8. Currently pregnant or breastfeeding

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Nasal Polyposis

Age (in years)

18 - 75


Phase 3

Participants needed


Est. Completion Date

Oct 10, 2025

Treatment type



AstraZeneca identifier


Study number


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