For Healthcare Professionals

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer


About the study

The main purpose of the study is to examine if periadjuvant (neoadjuvant, then adjuvant) immunotherapy will prolong event free survival in participants with early stage non-small cell lung cancer.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Participants with suspected or histologically confirmed Stage IIA (> 4 cm) to IIIB (T3N2) non-small cell lung carcinoma (NSCLC) with disease that is considered resectable
  2. No brain metastasis
  3. Treatment-naive for NSCLC (no prior systemic anti-cancer treatment)
  4. Ability to provide surgical or biopsy tumor tissue for biomarkers
  5. Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1


Exclusion Criteria:

  1. Participants with an active, known or suspected autoimmune disease
  2. Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV)
  3. Any previous anti-cancer treatment including cytotoxic, IO treatment, targeted agents, or radiotherapy for NSCLC
  4. Prior treatment with any anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways

Other protocol-defined inclusion/exclusion criteria apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Carcinoma, Non-Small-Cell Lung

Age (in years)



Phase 3

Participants needed


Est. Completion Date

Sep 30, 2024

Treatment type



Bristol-Myers Squibb identifier


Study number


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