For Healthcare Professionals

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

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About the study

This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

  1. Lp(a) ≥ 70 mg/dL at the screening visit, measured at the Central laboratory
  2. Myocardial infarction: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
  3. Ischemic stroke: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
  4. Clinically significant symptomatic peripheral artery disease Key

EXCLUSION CRITERIA

  1. Uncontrolled hypertension
  2. Heart failure New York Heart Association (NYHA) class IV
  3. History of malignancy of any organ system
  4. History of hemorrhagic stroke or other major bleeding
  5. Platelet count ≤LLN
  6. Active liver disease or hepatic dysfunction
  7. Significant kidney disease
  8. Pregnant or nursing women Other protocol-defined inclusion/
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 1-888-669-6682Email iconEmail Study Center

Study’s details


Contition

Cardiovascular Disease and Lipoprotein(a)

Age (in years)

18 - 80

Phase

Phase 3

Participants needed

8323

Est. Completion Date

May 2025

Treatment type

Interventional


Sponsor

Novartis

ClinicalTrials.gov identifier

NCT04023552

Study number

CTQJ230A12301

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