For Healthcare Professionals

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

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About the study

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

  1. Age ≥ 18 years.
  2. Histologically confirmed Grade IV GBM, inclusive of gliosarcoma (WHO criteria; IDH wild-type by immunohistochemistry [IHC] or sequencing for IDH) established following either a surgical resection or biopsy. An MRI scan with the required imaging sequences performed within 21 days prior to randomization preferably. The post-operative MRI scan performed within 96 hours of surgery or the MRI scan performed for radiation therapy planning may serve as the MRI scan performed during screening if all required imaging sequences were obtained.
  3. Karnofsky performance status ≥ 60% performed within a 14-day window prior to randomization.
  4. Availability of tumor tissue representative of GBM from definitive surgery or biopsy. Recurrent

EXCLUSION CRITERIA

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    Study Locations

    Enter your ZIP code/Postal code/PIN code to locate study sites near you:

    How to Apply


    Contact the study center to learn if this study is a good match for you.
    Phone iconCall 310-598-3199Email iconEmail Study Center

    Study’s details


    Contition

    Glioblastoma

    Age

    18+

    Phase

    Phase 2/Phase 3

    Participants needed

    1030

    Est. Completion Date

    Jun 2028

    Treatment type

    Interventional


    Sponsor

    Global Coalition for Adaptive Research

    ClinicalTrials.gov identifier

    NCT03970447

    Study number

    GCAR-7213

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