For Healthcare Professionals

An Investigational Immunotherapy Study of BMS-986301 Alone or in Combination With Nivolumab, and Ipilimumab in Participants With Advanced Solid Cancers


About the study

The main purpose of this study is to characterize the safety, tolerability, dose limiting toxicities, best route of administration, maximum tolerated dose, maximum administered dose, or alternative dose of BMS-986301 alone or in combination with nivolumab and ipilimumab in participants with cancers that have failed to respond to T cell checkpoint inhibiting antibodies.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Histologically or cytologically confirmed advanced unresectable/metastatic malignancy of the squamous cell carcinoma of the head and neck (HNSCC), non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), triple negative breast cancer (TNBC), and urothelial carcinoma (UCC), that are refractory to or intolerant of existing therapy(ies) known to provide clinical benefit for the condition of the participant
  2. Must have experienced radiographically documented progressive disease on or after the most recent therapy
  3. Eastern Cooperative Oncology Group (ECOG) score of 0 or 1
  4. Women and men must agree to follow specific methods of contraception, if applicable, while participating in the trial


Exclusion Criteria:

  1. Primary central nervous system (CNS) malignancy
  2. Other active malignancy requiring concurrent intervention
  3. Uncontrolled or significant cardiovascular disease

Other protocol defined inclusion/exclusion criteria apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Advanced Solid Cancers

Age (in years)



Phase 1

Participants needed


Est. Completion Date

Nov 28, 2025

Treatment type



Bristol-Myers Squibb identifier


Study number


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