For Healthcare Professionals

A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma

clipboard-pencil

About the study

The purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab by itself in treating unresectable melanoma or melanoma that has spread.
user-3

Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

  • For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com
  • Inclusion Criteria:


    1. Participants must have histologically confirmed Stage III (unresectable) or Stage IV melanoma, per the AJCC staging system
    2. Participants must not have had prior systemic anticancer therapy for unresectable or metastatic melanoma
    3. Tumor tissue from an unresectable or metastatic site of disease must be provided for biomarker analyses

    EXCLUSION CRITERIA

    Exclusion Criteria:


    1. Participants must not have active brain metastases or leptomeningeal metastases
    2. Participants must not have uveal melanoma
    3. Participants must not have an active, known, or suspected autoimmune disease

    Other protocol defined inclusion/exclusion criteria could apply


    pin location

    Study Locations

    Enter your ZIP code/Postal code/PIN code to locate study sites near you:

    How to Apply


    Contact the study center to learn if this study is a good match for you.

    Study’s details


    Contition

    Melanoma

    Age (in years)

    12+

    Phase

    Phase 2/Phase 3

    Participants needed

    714

    Est. Completion Date

    Dec 16, 2025

    Treatment type

    Interventional


    Sponsor

    Bristol-Myers Squibb

    ClinicalTrials.gov identifier

    NCT03470922

    Study number

    CA224047

    Understanding Clinical Trials


    Get answers to your questions about clinical trials.What is a clinical research?What does taking part in clinical trials involve?What should I ask the trial doctor?
    Vector

    Interested?

    Sign up to save your favorites, 
    receive newsletters, resources, and alerts 
    about clinical trials related to your conditions of interest.