For Healthcare Professionals

A Study of Atezolizumab (Anti-Pd-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients With High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck

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About the study

This study will evaluate the efficacy and safety of atezolizumab compared with placebo as adjuvant therapy after definitive local therapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck (SCCHN)
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

  1. Histologically or cytologically confirmed Squamous Cell Carcinoma of the Head and Neck (SCCHN)
  2. Human Papilloma Virus (HPV) status
  3. Completed definitive local therapy
  4. Absence of metastatic disease as documented by radiographic scans
  5. Adequate hematologic and end-organ function
  6. For patients receiving therapeutic anticoagulation: stable anticoagulant regimen
  7. For women of childbearing potential: agreement to remain abstinent or use contraceptive methods with a failure rate of < 1% per year during the treatment period and for 5 months after the last dose of study treatment. Women must refrain from donating eggs during this same period.
  8. Confirmed response of Complete Response (CR), Partial Response (PR), or Stable Disease (SD) to definitive local therapy documented by CT with contrast or MRI with contract to head and neck region done >= 8 weeks after completion of definitive local therapy and within 28 days prior to initiation of study drug.

EXCLUSION CRITERIA

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  1. Patients who have received surgery alone or radiotherapy alone as definitive local therapy
  2. Squamous cell carcinoma of the nasopharynx or paranasal sinuses or non-squamous histology
  3. Evidence of disease progression or metastatic disease during or following definitive local therapy documented in post-definitive local therapy screening scans
  4. Uncontrolled or symptomatic hypercalcemia
  5. Active or history of autoimmune disease or immune deficiency
  6. Active tuberculosis
  7. Significant cardiovascular disease
  8. History of malignancy, including prior SCCHN primary tumors within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death
  9. Prior allogeneic stem cell or solid organ transplantation
  10. Current treatment with anti-viral therapy for Hepatitis B Virus (HBV)
  11. Treatment with systemic immunostimulatory agents
  12. Treatment with systemic immunosuppressive medication
  13. History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins
  14. Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment or within 5 months after the last dose of study treatment
  15. Patients who have received a non-FDA or non-EMA approved anti-EGFR agent or any other non-FDA or non-EMA, approved agent as part of definitive local therapy, unless the unapproved agent was given in addition to an approved agent
  16. Any systemic therapies after permitted definitive local therapies
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 888-662-6728 (U.S. and Canada)Email iconEmail Study Center

Study’s details


Contition

Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Age

18+

Phase

Phase 3

Participants needed

406

Est. Completion Date

Jun 2027

Treatment type

Interventional


Sponsor

Hoffmann-La Roche

ClinicalTrials.gov identifier

NCT03452137

Study number

WO40242

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