For Healthcare Professionals

An Investigational Immunotherapy Study of BMS-986258 Alone and in Combination With Nivolumab in Participants With Solid Cancers That Are Advanced or Have Spread


About the study

The purpose of this study is to determine whether BMS-986258 both monotherapy and in combination with Nivolumab is safe and tolerable in the treatment of advanced malignant tumors.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


  1. Histologic confirmation of one of the 5 tumors [renal cell carcinoma (RCC), colorectal cancer (CRC), non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head and neck (SCCHN), triple negative breast cancer (TNBC)] (metastatic, recurrent, and/or unresectable), with measurable disease per response evaluation criteria in solid tumors v1.1 (RECIST v1.1)
  2. Eastern Cooperative Oncology Group Performance Status of 0 or 1
  3. Participants must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to solid tumor histologies
  4. Women must agree to follow specific methods of contraception, if applicable


  1. Active, known or suspected autoimmune disease
  2. Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior anti-cancer therapy and initiation of study therapy
  3. Other active malignancy requiring concurrent intervention Other protocol-defined inclusion/exclusion criteria apply
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.
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Study’s details


Advanced Cancer




Phase 1/Phase 2

Participants needed


Est. Completion Date

Mar 2023

Treatment type



Bristol-Myers Squibb identifier


Study number


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