For Healthcare Professionals

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation


About the study

This study will investigate if nivolumab will improve recurrence-free survival (RFS) compared to placebo in participants with HCC who have undergone complete resection or have achieved a complete response after local ablation, and who are at high risk of recurrence

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria:

  1. Participants with a first diagnosis of HCC who have undergone a curative resection or ablation
  2. Participants are eligible to enroll if they have non-viral related-HCC, or if they have HBV-HCC, or HCV-HCC
  3. Child-Pugh Score 5 or 6
  4. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1


Exclusion Criteria:

  1. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
  2. Any evidence of tumor metastasis or co-existing malignant disease
  3. Participants previously receiving any prior therapy for HCC, including loco-regional therapies
  4. Participants who have undergone a liver transplant or those who are in the waiting list for liver transplantation
  5. Participants who have received a live/attenuated vaccine within 30 days of randomization (eg, varicella, zoster, yellow fever, rotavirus, oral polio and measles, mumps, rubella [MMR]).

Other protocol defined inclusion/exclusion criteria apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Hepatocellular Carcinoma,Liver Cancer

Age (in years)



Phase 3

Participants needed


Est. Completion Date

Dec 16, 2025

Treatment type



Bristol-Myers Squibb identifier


Study number


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