For Healthcare Professionals

Study Investigating the Safety and Efficacy of Blinatumomab in Combination With Pembrolizumab in Adults With Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL)


About the study

The primary objective of the study is to determine the maximum tolerated dose (MTD) of blinatumomab in combination with pembrolizumab in adults with relapsed or refractory (r/r) DLBCL.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


  1. Have histologically confirmed diffuse large B-cell lymphoma that is either:
  2. Refractory after at least one regimen of systemic chemotherapy and/or targeted therapy, or
  3. In first or later relapse if have received at least 2 systemic regimens since time of diagnosis, or
  4. Relapsed post-autologous or allogeneic hematopoietic stem cell transplantation (HSCT) with adequate organ function after proximity to transplantation time exclusions
  5. Have measurable disease
  6. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
  7. Life expectancy of ≥ 12 weeks in the opinion of the Investigator
  8. Biopsy proven DLBCL (biopsy proven at least at primary diagnosis of DLBCL) Other Inclusion Criteria May Apply


  1. Richter's transformation (DLBCL arising in the setting of prior chronic lymphocytic leukemia) or primary mediastinal B cell lymphoma (PMBCL)
  2. History or presence of clinically relevant central nervous system pathology such as epilepsy, paresis, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis.
  3. Has a diagnosis of immunodeficiency or has received systemic steroid therapy (in excess of 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of protocol specified therapy.
  4. Has undergone prior allogeneic HSCT:
  5. within the last 5 years OR
  6. greater than 5 years ago but has active graft versus host disease (GvHD) requiring systemic treatment.
  7. Has received autologous HSCT within 6 weeks prior to start of treatment. Other Exclusion Criteria May Apply.
pin location

Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.
Phone iconCall 866-572-6436Email iconEmail Study Center

Study’s details


Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL)

Age (in years)

18 - 100


Phase 1

Participants needed


Est. Completion Date

Aug 2023

Treatment type



Amgen identifier


Study number


Understanding Clinical Trials

Get answers to your questions about clinical trials.What is a clinical research?What does taking part in clinical trials involve?What should I ask the trial doctor?


Sign up to save your favorites, 
receive newsletters, resources, and alerts 
about clinical trials related to your conditions of interest.