For Healthcare Professionals

Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

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About the study

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

For Dose Escalation Phase:

  1. Have any histologically
  2. or cytologically-confirmed advanced/metastatic solid tumor (except NSCLC for Cohorts 2 and 3) by pathology report and have received, been intolerant to, been ineligible for, or refused all treatment known to confer clinical benefit For Dose Confirmation Phase NSCLC Arms (A, B, C, and E):
  3. Have newly diagnosed histologically or cytologically-confirmed stage IIIB/stage IV NSCLC. Epidermal growth factor receptor (EGFR)-and anaplastic lymphoma kinase (ALK) translocation-directed therapy is not indicated as primary therapy. Participant must not have received prior systemic treatment for advanced NSCLC or must have received previous neoadjuvant and adjuvant chemotherapies ≥6 months before dosing of study drug if prior systemic treatment was given for early stage disease For Dose Confirmation Phase SCLC Arm (Arm D):
  4. Have histologically
  5. or cytologically-confirmed metastatic (Stage III/IV) SCLC with progressive disease after ≥1 platinum-based chemotherapy regimen. Participants with platinum-sensitive disease are eligible
  6. Have measurable disease by RECIST 1.1 as assessed by the local site investigator/radiology
  7. Have Eastern Cooperative Oncology Group (ECOG) Performance Scale status of 0 or 1
  8. A female participant is eligible to participate if she is not pregnant or breastfeeding and at least 1 of the following conditions applies:
  9. Is not a woman of child bearing potential (WOCBP) OR
  10. Is a WOCBP and using a contraceptive method that is highly effective during the intervention period and for at least 120 days after the last dose of pembrolizumab or pembrolizumab/quavonlimab, whichever comes last
  11. Female participants of childbearing potential must have negative urine or serum pregnancy test within 24 hours for urine and within 72 hours for serum prior to receiving the first dose of study treatment
  12. Male participants with a female partner(s) of child-bearing potential must be willing to use an adequate method of contraception for the course of the study through 120 days after the last dose of study medication and refrain from donating sperm during this period
  13. Must submit an evaluable baseline tumor sample for analysis (either a recent or archival tumor sample) For Efficacy Expansion Phase Arms F and G:
  14. Have histologically/cytologically-confirmed unresectable Stage III or Stage IV melanoma per American Joint Committee on Cancer (AJCC) staging system version 8, not amenable to local therapy
  15. Have at least 1 measurable lesion by CT or MRI per RECIST 1.1 by BICR. Cutaneous lesions and other superficial lesions are not considered measurable lesions for the purposes of this protocol, but may be considered as non-target lesions
  16. Participants with unresectable Stage III or IV disease must have progressed on treatment with an anti-PD-1/L1 monoclonal antibody (mAb) administered either as monotherapy, or in combination with other checkpoint inhibitors or other therapies (combinations with anti-cytotoxic T-lymphocyte associated protein 4 [CTLA-4] agents will not be allowed)
  17. Participants who receive anti-PD-1 therapy as adjuvant treatment following complete resection of Stage III or IV melanoma and have disease recurrence (unresectable loco-regional disease or distant metastases) while on active treatment or within 6 months of stopping anti-PD-1 are eligible
  18. Have submitted pre-trial imaging and provided a baseline tumor sample
  19. Proto-oncogene B-raf (BRAF) V600 mutation-positive melanoma participants should have received targeted therapy for advanced or metastatic disease (eg, BRAF/MEK inhibitor, alone or in combination) prior to enrolling on this study; however, they are not required to progress on this treatment prior to enrollment
  20. BRAF V600E mutation-positive melanoma participants who have NOT received a BRAF inhibitor (either as adjuvant therapy or in the metastatic disease setting) with lactate dehydrogenase (LDH) < local upper limit of normal (ULN), no clinically significant tumor-related symptoms, and absence of rapidly progressing metastatic melanoma. Approximately 10 participants each from Arms F and G will have 2 mandatory biopsies For Dose Coformulation Phase Arm I:
  21. Have any histologically
  22. or cytologically-confirmed advanced/metastatic solid tumor by pathology report and have received, been intolerant to, been ineligible for or refused all treatment known to confer clinical benefit
  23. Meet all requirements for Dose Escalation Phase and Dose Confirmation Phase For the Coformulation Phase
  24. Arm K (China only):
  25. Have any histologically
  26. or cytologically-confirmed advanced/metastatic solid tumor by pathology report and have received, been intolerant to, been ineligible for, or refused all treatment known to confer clinical benefit
  27. Be a Chinese participant residing in China.

EXCLUSION CRITERIA

  1. For all phases of the study: Has received previous treatment with another agent targeting cytotoxic T lymphocyte leukocyte antigen (CTLA)-4 For Dose Confirmation Phase:
  2. Has received previous treatment with another agent targeting programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor
  3. Has had chemotherapy, definitive radiation, or biological cancer therapy within 4 weeks (2 weeks for palliative radiation) prior to the first dose of study therapy, or has not recovered to Common Toxicity Criteria for Adverse Events (CTCAE) Grade 1 or better from any AEs that were due to cancer therapeutics administered more than 4 weeks earlier
  4. Has received lung radiation therapy of >30 Gray (Gy) within 6 months before the first dose of study treatment
  5. Is currently participating and receiving study therapy in a study of an investigational agent or has participated and received study therapy in a study of an investigational agent or has used an investigational device within 28 days of administration of quavonlimab.
  6. Has a history of a second malignancy, unless potentially curative treatment has been completed with no evidence of malignancy for 3 years For Dose Escalation Cohorts (1-3) and Dose Confirmation Arms (A-E):
  7. Has known untreated central nervous system (CNS) metastases. Has known carcinomatous meningitis
  8. Has received any prior immunotherapy and was discontinued from that treatment due to a Grade 3 or higher immune-related adverse events (irAE)
  9. Has had a severe hypersensitivity reaction to treatment with any monoclonal antibody or components of the study drug
  10. Has any active infection requiring therapy
  11. Has a history of interstitial lung disease, history of noninfectious pneumonitis that required steroids (or has current pneumonitis), or history of inflammatory bowel disease
  12. Has an active autoimmune disease that has required systemic treatment in the past 2 years
  13. Has clinically significant cardiac disease
  14. Has received a live or live attenuated vaccine within 28 days of planned treatment start
  15. Has known history of human immunodeficiency virus (HIV) and/or known active Hepatitis B or C infections, and/or known to be positive for hepatitis B surface antigen (HBsAg)/ hepatitis B virus (HBV) DNA
  16. Has known psychiatric or substance abuse disorders that would interfere with the participant's ability to cooperate with the requirements of the trial
  17. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study, starting with screening and for up to 120 days following cessation of pembrolizumab or pembrolizumab/quavonlimab
  18. Has not fully recovered from any effects of major surgery without significant detectable infection For Arm F and G (Efficacy Expansion Phase) and Arm K (Coformulation Phase) ONLY:
  19. Has known active CNS metastases and/or carcinomatous meningitis
  20. Has not had resolution of anti-PD-1 antibody-related AEs, including immune-mediated AEs back to Grade ≤1 or baseline (not applicable to Arm K)
  21. Has not discontinued steroid treatment for an irAE for at least 2 weeks prior to the first dose of study drug (not applicable to Arm K)
  22. Has ocular melanoma (not applicable to Arm K)
  23. Has mucosal melanoma (not applicable to Arm K)
  24. Has had an allogenic tissue/solid organ transplant
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
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Study’s details


Contition

Advanced Solid Tumors

Age

18+

Phase

Phase 1/Phase 2

Participants needed

348

Est. Completion Date

Oct 2023

Treatment type

Interventional


Sponsor

Merck Sharp & Dohme LLC

ClinicalTrials.gov identifier

NCT03179436

Study number

MK-1308-001

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