A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin

Inclusion Criteria:

1. Must have histologically confirmed squamous cell carcinoma or adenosquamous cell carcinoma of esophagus
2. Male or Female at least 18 years of age
3. Must have esophageal cancer that cannot be operated on, or treated with definitive chemoradiation with curative intent, that is advanced, reoccurring or has spread out
4. Must have full activity or, if limited, must be able to walk and carry out light activities such as light house work or office work
5. Must agree to provide tumor tissue sample, either from a previous surgery or biopsy within 6 months or fresh, prior to the start of treatment in this study

Exclusion Criteria

1. Presence of tumor cells in the brain or spinal cord which are symptomatic or require treatment
2. Active known or suspected autoimmune disease
3. Any serious or uncontrolled medical disorder or active infection
4. Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
5. Any positive test result for hepatitis B or C indicating acute or chronic infection and/or detectable virus

Other protocol defined inclusion/exclusion criteria apply