Biomarker Guided Discharge of Heart Failure Patients

Inclusion Criteria:

Patients admitted to hospital with a primary diagnosis of acute decompensated heart failure, compatible with the modified Framingham criteria

Exclusion Criteria:

Patient unable to provide blood samples or cannot participate in follow-up

Patient with end stage organ failure

1. Kidney: creatinine >350 μmol/L or Estimated GFR ≤15 ml/min
2. Liver dysfunction: liver function test >2.5 times normal
3. Lungs: pulmonary FEV1<50% predicted
4. Patient requiring intubation
5. Patient with an admission NTproBNP measurement of >30,000 pg/ml
6. Patient listed for heart transplant, or admitted specifically for transplant workup
7. Patient in cardiogenic shock
8. Patient with life expectancy of less than 6 months, or has major co-morbidities such as new stroke, cancer, pneumonia, or other serious life threatening illness
9. Patient with conditions that will make it difficult to discharge from hospital such as a fall or waiting for a long term care bed
10. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the patient at risk because of participation in the trial, or may bias the result of the trial, or the patient's ability to participate in the trial
11. Patient who has participated in another research trial involving an investigational product in the past 30 days