For Healthcare Professionals

Study of Durvalumab Alone or Chemotherapy for Patients With Advanced Non Small-Cell Lung Cancer (PEARL)


About the study

This is a randomized, open-label, multi-center Phase III study to determine the efficacy and safety of durvalumab versus platinum-based SoC chemotherapy in the first-line treatment of advanced NSCLC in patients who are epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type and with PD-L1 high expression (PEARL)

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


Inclusion Criteria

  1. Aged at least 18 years
  2. Documented evidence of Stage IV NSCLC
  3. No sensitizing EGFR mutation and ALK rearrangement
  4. PD-L1 high expression
  5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1


Exclusion Criteria:

  1. Prior chemotherapy or any other systemic therapy for advanced NSCLC
  2. Prior exposure to immune-mediated therapy, including, but not limited to, other anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), anti-programmed cell death1 (PD-1), anti-programmed cell death ligand 1 (PD-L1), or anti PD-L2 antibodies, excluding therapeutic anticancer vaccines
  3. Brain metastases or spinal cord compression unless the patient is stable and off steroids for at least 14 days prior to start of study treatment
  4. Mixed small-cell lung cancer and NSCLC histology, sarcomatoid variant
  5. Active or prior documented autoimmune or inflammatory disorders (e.g., colitis or Crohn's disease]

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Non Small Cell Lung Carcinoma NSCLC

Age (in years)

18 - 130


Phase 3

Participants needed


Est. Completion Date

Aug 20, 2026

Treatment type



AstraZeneca identifier


Study number


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