A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Inclusion Criteria:

1. Have an Eastern Cooperative Oncology Group performance status of 0 or 1.
2. Have a histologically or cytologically confirmed diagnosis of non-resectable, recurrent, or metastatic biliary tract adenocarcinoma (intrahepatic or extrahepatic cholangiocarcinoma, gallbladder cancer, or Ampulla of Vater) .
3. Have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST).
4. Have adequate biliary drainage.
5. Have adequate organ function.
6. Males and females are sterile, postmenopausal, or compliant with a highly effective contraceptive method.
7. Female participants of childbearing potential must have a negative serum pregnancy test within 7 days prior to first dose.
8. Are willing to provide blood/serum/plasma and tumor tissue samples for research purposes. Submission of blood/serum/plasma and tumor tissue samples is mandatory for participation in this study, unless restricted per local regulations.

Exclusion Criteria:

1. Previous systemic therapy for locally advanced or metastatic disease is not allowed.
2. Have a history of or have current hepatic encephalopathy of any grade, or ascites of Grade >1, or cirrhosis with Child-Pugh Stage B or higher.
3. Have ongoing or recent (≤6 months) hepatorenal syndrome.
4. Have had a major surgical procedure or significant traumatic injury including nonhealing wound, peptic ulcer, or bone fracture ≤28 days prior to randomization.
5. Anticipate having a major surgical procedure during the course of the study.
6. Has documented brain metastases, leptomeningeal disease, or uncontrolled spinal cord compression.
7. Within 6 months prior to randomization, have had any arterial thrombotic event, including myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack.
8. Have an uncontrolled arterial hypertension with systolic blood pressure ≥150 or diastolic blood pressure ≥90 millimeters of mercury (mm Hg) despite standard medical management.
9. Have a previous malignancy within 5 years of study entry or a concurrent malignancy.
10. Have a history of gastrointestinal perforation and/or fistulae within 6 months prior to randomization.
11. Have a known allergy or hypersensitivity reaction to any of the treatment components.
12. Have a history of uncontrolled hereditary or acquired thrombotic disorder.
13. Have uncontrolled metabolic disorders or other nonmalignant organ or systemic diseases or secondary effects of cancer that induce a high medical risk and/or make assessment of survival uncertain.
14. Have mixed hepatocellular biliary tract cancer histology.
15. Have a corrected QT interval >470 milliseconds as calculated by the Fridericia equation.