For Healthcare Professionals

A Pragmatic Randomized Trial to Evaluate the Comparative Effectiveness Between Dapagliflozin and Standard of Care in Type 2 Diabetes Patients


About the study

A trial of patients with type 2 diabetes mellitus to evaluate the comparative effectiveness between dapagliflozin and Standard of Care (SOC)

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


For inclusion in the study patients should fulfil the following criteria at the time of screening:

  1. Provision of informed consent prior to any study specific procedures
  2. Females and males aged ≥18 years up to ≤ 75 years
  3. Diagnosed with Type 2 Diabetes Mellitus.
  4. Uncontrolled on first-line metformin treatment, defined as ≥8 weeks on maximum tolerated dose of metformin and HbA1c > 6.5%.
  5. Ability to read and write as judged by the investigator.


Patients should not enter the study if any of the following exclusion criteria are fulfilled:

  1. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site)
  2. Previous enrolment or randomization in the present study
  3. Age > 75 years
  4. Pregnancy/active breast feeding at the time of inclusion
  5. Known moderate to severe renal impairment (eGFR<60ml/min).
  6. Participation in an interventional clinical trial ≤ 3 months before enrolment.
  7. Unsuitable to participate on mental health grounds, as judged by the investigator.
  8. Physician decision to use, as second line treatment, insulin, a GLP1 agonist compound or a SGLT2 inhibitor different from dapagliflozin.
  9. Presence of any of the characteristics in which the products in study are contraindicated, as per current labels.
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply

Contact the study center to learn if this study is a good match for you.
Phone iconCall 1-877-240-9479Email iconEmail Study Center

Study’s details


Type 2 Diabetes Mellitus,Dry Eye


Phase 4

Participants needed


Est. Completion Date

Jun 2023

Treatment type



University of Liverpool identifier


Study number


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