A Study of LY2875358 in Participants With Non-Small Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations

Inclusion Criteria:

1. Histologically or cytologically confirmed diagnosis of metastatic Stage IV NSCLC
2. Have at least 1 measurable lesion whose presence is assessable using standard techniques by Response Evaluation Criteria in Solid Tumors (RECIST version 1.1)
3. Have molecular evidence of an epidermal growth factor receptor mutation (EGFRmt) known to be associated with EGFR tyrosine kinase inhibitor (TKI) drug sensitivity (G719X, exon 19 deletion, L858R, L861Q)
4. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2
5. Haven't received any prior systemic chemotherapy for Stage IV NSCLC (unless received as neoadjuvant or adjuvant therapy for early-stage NSCLC disease and completed therapy at least 6 months prior to enrollment)
6. Availability of adequate tumor material (block or slides)

Exclusion Criteria:

1. Are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational product or non-approved use of a drug or device
2. Have previously completed or withdrawn from this study or any other study investigating LY2875358
3. Have a serious concomitant systemic disorder or significant cardiac disease
4. Have interstitial pneumonia or interstitial fibrosis of the lung or have pleural effusion, pericardial fluids or ascites, requiring drainage every other week or more frequently
5. Have a history of another malignancy except for basal or squamous cell skin cancer and/or in situ carcinoma of the cervix, or other solid tumors treated curatively and without evidence of recurrence for at least 3 years prior to the study
6. Have major surgery less than 2 weeks prior to the initiation of study treatment therapy
7. Pregnant or lactating women