For Healthcare Professionals

A Study in Recurrent Glioblastoma (GB)

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About the study

The purpose of the study is to see whether treatment with LY2157299 on its own, LY2157299 plus lomustine therapy or lomustine plus placebo can help participants with brain cancer
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

  1. Histological confirmed diagnosis of relapsed intracranial GB
  2. Progressive Disease (PD) following standard chemoradiation
  3. Prior surgical resection allowed
  4. Performance status Eastern Cooperative Oncology Group (ECOG) 0 or 1
  5. Adequate hematologic, hepatic and renal function
  6. Discontinued all prior cancer treatments for cancer & recovered from the acute effects of therapy
  7. Tumor specimen must be available for a central pathology review and prognostic and predictive biomarker evaluation

EXCLUSION CRITERIA

  1. Moderate or severe heart disease based on New York Heart Association (NYHA) criteria
  2. Prior nitrosurea therapy (including lomustine or Gliadel)
  3. Prior bevacizumab as 1st line treatment for GB (if treatment was concluded 12 months prior to enrollment, the patient may be eligible to participate in the trial)
  4. Current acute or chronic myelogenous leukemia
  5. Second primary malignancy that may affect the interpretation of results
  6. Serious concomitant systemic disorder
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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.

Study’s details


Contition

Glioblastoma

Age (in years)

18 - 200

Phase

Phase 2

Participants needed

180

Est. Completion Date

Dec 2023

Treatment type

Interventional


Sponsor

Eli Lilly and Company

ClinicalTrials.gov identifier

NCT01582269

Study number

H9H-MC-JBAL

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