For Healthcare Professionals

Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass


About the study

The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using tNIRS and vascular occlusion test (VOT) in elective on pump cardiac surgery patients using a non-invasive near infrared spectrometry (NIRS) machine. The clinical implications are that NIRS may permit earlier, non-invasive detection of significant physiologic derangements and allow more accurate and timely titration of medications, fluids and surgical intervention. The use of a low dose vasopressin seems to be preventive for the incidence of observed post-cardiotomy vasodilatory shock and may improve the function of microcirculation that will be assessed using VOT and tNIRS. Finally, it may decrease both catecholamine dose and duration of their administration, it is considered as a useful agent for decreasing all heir side-effects

Who can take part

You may be eligible to participate in the study if you meet the following criteria:


  1. Adult, elective cardiac surgery patients with the use of cardiopulmonary bypass (CPB)


  1. Age less than 18 years
  2. Contraindication to pneumatic cuff inflation (arteriovenous fistula, previous mastectomy, injury to arm)
  3. Pregnancy
  4. Significant peripheral vascular disease of the arms*
  5. Emergency surgery
  6. Uncured cancer during chemotherapy
  7. Lack of informed consent
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Study Locations

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How to Apply

Contact the study center to learn if this study is a good match for you.

Study’s details


Hypotension,Poor Peripheral Perfusion

Age (in years)

18 - 200



Participants needed


Est. Completion Date

Dec 2012

Treatment type



London Health Sciences Centre identifier


Study number


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