Analysis of Specimens From Individuals With Pulmonary Fibrosis

INCLUSION CRITERIA:

Individuals who are 18 years of age or older with any of the following:

1. Idiopathic pulmonary fibrosis [defined by the American Thoracic Society/European Respiratory Society guidelines],
2. Familial pulmonary fibrosis [defined as idiopathic pulmonary fibrosis in two or more first-degree relatives],
3. Relatives of patients with hereditary pulmonary fibrosis,
4. Hermansky-Pudlak syndrome (diagnosed by paucity or deficiency of platelet dense bodies on whole mount electron microscopy or by genetic testing),
5. Pulmonary fibrosis associated with collagen vascular diseases or autoinflammatory disorders,
6. Pulmonary fibrosis post-COVID-19 [i.e., pulmonary fibrosis in an individual recovering from SARS-CoV-2 infection], or
7. Healthy research volunteers by history and indicated tests (individuals without history of chronic pulmonary disorder, collagen vascular disease, or bleeding disorder).

EXCLUSION CRITERIA:

Individuals with any of the following:

1. Significant inhalational exposure to fibrogenic fibers or dusts or exposure to drugs associated with pulmonary fibrosis,
2. Uncontrolled ischemic heart disease,
3. Uncorrectable bleeding diathesis,
4. Pregnancy or lactation (excluded due to exposure of unnecessary risks), or
5. Inability to give informed consent (excluded due to exposure of unnecessary risks).